Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis

Wnt signaling specifies and patterns intestinal endoderm

Wnt signaling has been implicated in many developmental processes, but its role in early endoderm development is not well understood. Wnt signaling is active in posterior endoderm as early as E7.5. Genetic and chemical activation show that the Wnt pathway acts directly on endoderm to induce the intestinal master regulator Cdx2, shifting global gene away from anterior endoderm and toward a poste...

Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

The embryonic stem cell differentiation system was used to define the roles of the Activin/Nodal, BMP, and canonical Wnt signaling pathways at three distinct developmental stages during hematopoietic ontogeny: induction of a primitive streak-like population, formation of Flk1(+) mesoderm, and induction of hematopoietic progenitors. Activin/Nodal and Wnt, but not BMP, signaling are required for ...

Is Timing Everything?

Thank you Ben and AmSECT for organizing this conference. And thank you all for showing up on Saturday morning. My objectives for this presentation are to review the current knowledge of time spent below critical thresholds and more specifically the relationship between low oxygen delivery and organ function following cardiopulmonary bypass (CPB). Additionally, we will investigate the time–dose ...

Timing Is Everything?

Timing Is Everything

cated in depression of sensory responses in superficial layers of the cortex following whisker deprivation (Glazewski and Fox, 1996). To test whether the relative timing of pre-and postsynaptic activity has an effect Changes in sensory experience are capable of produc-on cortical plasticity, Feldman prepared slices of barrel ing changes in sensory transmission within the neocor-cortex and made ...